Medical management of clomiphene-resistant polycystic ovarian syndrome: an update

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Laparoscopic Ovarian Drilling versus Medical Treatment in Management of Clomiphene Citrate Polycystic Ovarian Syndrome

A literature search was conducted with Google search engine, Highwire press and PubMed. Laparoscopic ovarian drilling, polycystic ovarian syndrome, clomiphene citrate, metformin, GnRHa with polycystic ovaries were entered as search words. Articles were selected for review from all the citations produced from the search. These were selected based on predetermined criteria as stated below. 1. Yea...

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Laparoscopic Ovarian Drilling for Polycystic Ovarian Syndrome in Clomiphene Citrate-Resistant Women with Anovulatory Infertility

Results: Follow-up data, which were available for 181 patients, showed a spontaneous ovulation rate of 70.1%, cumulative ovulation rate of 98.3%, and pregnancy rate of 84.5%. Women who conceived following surgery were obese, had higher pre-operative luteinizing hormone (LH) levels, were younger and were more likely to have typical ultrasonographic features of polycystic ovarian disease. Logisti...

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Effect of Laparoscopic Ovarian Drilling on Outcomes of In Vitro Fertilization in Clomiphene-Resistant Women with Polycystic Ovary Syndrome

Objective Recently the laparoscopic ovarian drilling (LOD) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (PCOS), although its mechanism and outcomes are still unclear. This study was undertaken to evaluate the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes in clomiphene-resistant women with PCOS who were treated with...

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Pregnancy following laparoscopic ovarian drilling for clomiphene resistant polycystic ovarian syndrome.

We present a case of a 29 year old nulliparous woman with clomiphene resistance polycystic ovarian syndrome. She had a successful laparoscopic ovarian drilling (LOD) in a private fertility centre in Nnewi Southeast Nigeria. She achieved a pregnancy four months later following clomiphene citrate ovulation induction. The pregnancy was complicated with 1st trimester threatened abortion, pre-term P...

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Naltrexone treatment in clomiphene resistant women with polycystic ovary syndrome.

BACKGROUND Endogenous opiates may affect various aspects of reproductive and metabolic function in patients with polycystic ovary syndrome (PCOS). This study evaluated long-term inhibition of the opioid system using naltrexone in clomiphene citrate (CC)-resistant women with PCOS. METHODS A group of 30 infertile females with PCOS were evaluated; all subjects were obese, hyperandrogenic and hyp...

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ژورنال

عنوان ژورنال: International Journal of Basic & Clinical Pharmacology

سال: 2014

ISSN: 2319-2003

DOI: 10.5455/2319-2003.ijbcp20140232